Author

T. de Souza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Drost· 3 shared J. DeMartino· 2 shared L. S. Hiemcke-Jiwa· 2 shared M. Brok· 2 shared M. J. A. Groot Koerkamp· 2 shared M. T. Meister· 2 shared T. Margaritis· 2 shared A. Balwierz· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

J. Drost

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC.

M. Ganpat, F. Morales-Rodriguez, N. Pham, P. Lijnzaad, T. de Souza, S. Derakhshan, A. Fumagalli, P. Zeller, A. Balwierz, D. Ayyildiz, M. M. van den Heuvel-Eibrink, R. R. de Krijger, A. van Oudenaarden, T. Margaritis, S. M. Chuva de Sousa Lopes, J. Drost

This study creates an engineered tumor organoid model of tRCC using SFPQ-TFE3 fusion expression, revealing epithelium-to-mesenchymal differentiation and Wnt signaling involvement in tumor transformation.

bioRxiv · Sep 1, 2023 · PreprintCancer Biology

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma.

J. DeMartino, M. T. Meister, L. Visser, M. Brok, M. J. A. Groot Koerkamp, L. S. Hiemcke-Jiwa, T. de Souza, J. Merks, F. C. Holstege, T. Margaritis, J. Drost

This study uses single-cell transcriptomics to identify immune suppression and cell states in rhabdomyosarcoma that predict patient outcomes.

bioRxiv · Jul 15, 2022 · PreprintCancer Biology

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

M. T. Meister, M. J. A. Groot Koerkamp, T. de Souza, W. B. Breunis, E. Frazer-Mendelewska, M. Brok, J. DeMartino, F. Manders, C. Calandrini, H. H. D. Kerstens, A. Janse, M. E. M. Dolman, S. Eising, K. P. S. Langenberg, M. van Tuil, , F. C. P. Holstege

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

bioRxiv · Jan 3, 2022Cancer Biology

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

E. Tsagkaraki, S. Nicoloro, T. De Souza, J. Solivan-Rivera, A. Desai, Y. Shen, M. Kelly, A. Guilherme, F. Henriques, R. Ibraheim, N. Amrani, K. Luk, S. Maitland, R. H. Friedline, L. Tauer, , M. P. Czech

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

bioRxiv · Oct 13, 2020Bioengineering