A. van Oudenaarden

Acute multi-level response to defective de novo chromatin assembly in S-phase

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC.

This study creates an engineered tumor organoid model of tRCC using SFPQ-TFE3 fusion expression, revealing epithelium-to-mesenchymal differentiation and Wnt signaling involvement in tumor transformation.

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo

The paper introduces a method to identify stress granule RNAs using RNA-editing in single cells and tissues, revealing 398 neuronal stress granule mRNAs in Drosophila.

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart

This study identifies a metabolic switch from OXPHOS to glycolysis in regenerating zebrafish hearts, showing it is essential for cardiomyocyte proliferation and heart regeneration.

Long-term expanding human airway organoids for disease modelling.

This study establishes long-term-expanding human airway organoids from broncho-alveolar biopsies or lavage material, enabling disease modeling of cystic fibrosis, lung cancer, and RSV infection.