N. Jameson

Improving protein expression, stability, and function with ProteinMPNN

This paper introduces ProteinMPNN, a deep learning model that improves protein expression, stability, and function by incorporating evolutionary and structural information.

The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

This study shows that the Axin scaffold prevents GSK3β from being phosphorylated at Ser9 by upstream kinases, thereby protecting Wnt signaling from cross-pathway inhibition.