Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq
Tuo Shi, Maria V. Korshunova, Seoyeon Kim, David DeTomaso, Xinhe Zheng, Lavanya Vishvanath, Thokozile Nyasulu, Nhan Huynh, Alexander Sun, Patrick C. Thompson, Yifan Zhang, Emilie M. Wigdor, Narjes Rohani, Salma Ali, Huixian Qiu, , Xin Jin
The paper maps gene expression responses to loss of 1,947 disease-associated genes across the mouse brain using Perturb-seq, revealing cell-type-specific essentiality and transcriptional programs.
bioRxiv · Mar 18, 2026 · PreprintGenomics