Yifan Zhang

A PERTURBATION CELL ATLAS OF HUMAN INDUCED PLURIPOTENT STEM CELLS

The paper generates a CRISPRi perturbation cell atlas in human induced pluripotent stem cells, identifies novel regulators of pluripotency and metabolism, and proposes a machine learning framework for predicting perturbation recipes.

A specific computational role for early-life unpredictability, and not lifelong stressful experience, in decision-making under uncertainty.

This study shows early-life unpredictability affects decision-making under uncertainty by increasing discounting and overharvesting, distinct from lifelong stress effects.

Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making.

This study examines how anhedonia and early-life unpredictability interact to influence threat-reward decision-making in humans.

Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq

The paper maps gene expression responses to loss of 1,947 disease-associated genes across the mouse brain using Perturb-seq, revealing cell-type-specific essentiality and transcriptional programs.

Multiplexed Pan Soluble Ligandome Assaying via OASIS

The paper introduces OASIS, a method to screen soluble ligands by enforcing autocrine signaling, and applies it to identify self-renewal factors in hiPSCs.

Two ways to learn in visuomotor adaptation

The paper investigates quantitative and qualitative differences in visuomotor adaptation by analyzing learning and forgetting rates, revealing two distinct learning strategies based on individual differences in fast and slow processes.

A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information

The paper shows that anterior cingulate cortex inhibition disrupts information-based choice preference in female rats, suggesting a sex-dependent role for ACC in decision-making involving information.