Nhan Huynh

The paper develops Perturb-CLEAR to study dendritic morphogenesis in the developing mouse cortex, revealing gene-specific multimodal phenotypes linked to NDD risk genes.

The paper maps gene expression responses to loss of 1,947 disease-associated genes across the mouse brain using Perturb-seq, revealing cell-type-specific essentiality and transcriptional programs.

This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.

This paper introduces a method for targeted gene editing using RNA-templated DNA repair pathways in human cells, achieving high efficiency and fidelity.

This paper demonstrates the effectiveness of Cas13 for RNA manipulation in Drosophila, including targeting endogenous transcripts and editing mRNAs.

The paper develops CRISPR-Cas9 tools for spatial and temporal gene manipulation in Drosophila prothoracic gland, avoiding lethality caused by Cas9 overexpression.