Xinhe Zheng

Concordant transcriptional and morphological remodeling revealed by in vivo Perturb-CLEAR

The paper develops Perturb-CLEAR to study dendritic morphogenesis in the developing mouse cortex, revealing gene-specific multimodal phenotypes linked to NDD risk genes.

Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq

The paper maps gene expression responses to loss of 1,947 disease-associated genes across the mouse brain using Perturb-seq, revealing cell-type-specific essentiality and transcriptional programs.

In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture

This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.

Massively parallel in vivo Perturb-seq reveals cell type-specific transcriptional networks in cortical development

This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.