Modulation of cannabinoid receptor signaling by endocannabinoids
K. Krishna Kumar, M. J. Robertson, E. Thadhani, H. Wang, C.-M. Suomivuori, A. S. Powers, L. Ji, S. P. Nikas, M. Gerasi, K. Vemuri, R. Dror, A. Inoue, A. Makriyannis, G. Skiniotis, B. K. Kobilka
This study investigates how endocannabinoids modulate CB1 receptor signaling by comparing their activation of Gi1 with synthetic cannabinoids and revealing structural differences in ligand binding.
bioRxiv · Aug 6, 2022 · PreprintBiochemistry