Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5
A. Izadi, M. Godzwon, M. Ohlin, P. Nordenfelt
bioRxiv · Sep 29, 2023 · PreprintImmunology
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M. Godzwon
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2021-2023 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 38 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
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Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis
W. Bahnan, S. Wrighton, M. Sundwall, A. Bläckberg, O. Larsson, U. Höglund, H. Khakzad, M. Godzwon, M. Walle, E. Elder, L. Happonen, O. Andre, J. Kumra Ahnlide, T. Hellmark, V. Wendel-Hansen, , P. Nordenfelt
This study shows that non-neutralizing Spike-specific antibodies can enhance phagocytosis of SARS-CoV-2 by monocytes, potentially offering protection despite not neutralizing the virus.
bioRxiv · Oct 14, 2021Immunology