P. Nordenfelt

Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow

This paper develops a combined systems antigenomics-serology workflow to characterize circulating IgG against Group A Streptococcus, revealing antigen repertoire and functional properties of antibodies in healthy and infected individuals.

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

This study examines opsonic antibody responses to invasive S. pyogenes infections, finding modest increases in antibody binding and variable opsonic capacity across strains.

Group A streptococci induce high-affinity M protein-fibronectin interaction when specific human antibodies are bound

The paper shows that human antibodies can enhance the Fn-binding affinity of GAS M proteins by targeting a conserved region, allowing bacteria to bind Fn more efficiently without producing additional proteins.

Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis

This study shows that non-neutralizing Spike-specific antibodies can enhance phagocytosis of SARS-CoV-2 by monocytes, potentially offering protection despite not neutralizing the virus.

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infection

The paper describes a human monoclonal antibody that binds two distinct epitopes on streptococcal M protein via a bivalent dual-Fab cis mode, providing protection against infection.

Binding site localization on non-homogeneous cell surfaces using topological image averaging

This paper develops a method for imaging-based localization of antibody binding sites on cell surfaces, achieving nanometer-scale resolution through topological image averaging.

A predictive model of antibody binding in the presence of IgG-interacting bacterial surface proteins

The paper develops a biophysical model to predict antibody binding interactions with bacterial surface proteins and demonstrates its utility in predicting IgG treatment effects.

High-sensitivity assessment of phagocytosis by persistent association-based normalization

This paper introduces a method to assess phagocytosis using persistent prey-phagocyte association, showing improved robustness, sensitivity, and reproducibility compared to standard methods.

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

The paper shows that integrin orientation is dictated by actin flow direction and cytoskeletal forces during leukocyte migration.