M. Gough

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.

This study identifies UGDH as a driver of tumor-initiating cells and fibroinflammatory microenvironment in ovarian cancer, with subtype-specific effects on prognosis and tumor growth.

Glycogen phosphorylase inhibition alongside taxol chemotherapy synergistically elicits ferroptotic cell death in clear cell ovarian and kidney cancers

The paper shows that inhibiting glycogen phosphorylase with CP91149 synergizes with taxol to induce ferroptotic cell death in clear cell ovarian and kidney cancers.

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

The chromatin remodeler SMARCD3 regulates cell cycle progression and its expression predicts survival outcome in ER+ breast cancer

This paper shows SMARCD3 expression correlates with survival in ER+ breast cancer and regulates cell cycle progression, suggesting it as a prognostic biomarker and tumor suppressor.