T.-H. Lee

Native Korean wild mice (Mus musculus): molecular phylogeny and morphometrics

The paper analyzes genetic and morphological data of Korean wild mice to determine their phylogenetic relationships and taxonomic status within the Mus musculus subspecies.

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.

Defense-related callose synthase PMR4 promotes root hair callose deposition and adaptation to phosphate deficiency in Arabidopsis thaliana

This study identifies PMR4 callose synthase as essential for root hair callose deposition under phosphate deficiency, improving Pi acquisition and plant growth.

Histone H3 tail modifications regulate structure and dynamics of the H1 C-terminal domain within nucleosomes

The paper investigates how histone H3 tail modifications affect the structure and dynamics of the H1 C-terminal domain in nucleosomes using single-molecule FRET.

Spontaneous Histone Exchange Between Nucleosomes

This study demonstrates spontaneous histone exchange between nucleosomes using smFRET, showing it occurs on a tens of seconds timescale and is influenced by salt, acetylation, and Nap1.

The Effects of Histone H2B ubiquitylations and H3K79me3 on Transcription Elongation

This study investigates how histone modifications H2BK34ub, H2BK120ub, and H3K79me3 affect RNA Polymerase II transcription elongation kinetics using single-molecule FRET.

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

This paper computationally redesigns an antibody to restore potency against SARS-CoV-2 Omicron subvariants while maintaining efficacy against Delta and other variants.

Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

This study shows that oral administration of Thauera sp. strain GDN1 reduces serum androgen levels in male mice by catabolizing androgens in the gut.

Peroxiredoxin 5 regulates osteogenic differentiation via interaction with hnRNPK during bone regeneration

This study identifies Prdx5's role in bone regeneration by regulating osteoblast differentiation through interaction with hnRNPK, impacting osteocalcin expression and osteoclast activity.

A Tailored Approach To Study Legionella Infection Using Lattice Light Sheet Microscope (LLSM)

This study uses a modified Lattice Light Sheet Microscope to analyze Legionella pneumophila infection dynamics and morphology.

Enzyme Aggregation and Fragmentation Induced by Catalysis Relevant Species

The paper examines enzyme aggregation and fragmentation during catalysis in three model enzymes, finding that specific substrates and ions induce structural changes without affecting catalytic activity.

Endothelial restoration of CAD GWAS gene PLPP3 by nanomedicine suppresses YAP/TAZ activity and reduces atherosclerosis in vivo

This paper develops a nanomedicine approach to restore PLPP3 in endothelial cells, reducing YAP/TAZ activity and atherosclerosis in mice.

Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria

This study identifies essential β-oxidation genes and metabolites involved in estrogen degradation by actinobacteria using transcriptomics, gene disruption, and metabolite profiling.

Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate from estuarine sediments

This study identifies synergistic microbial networks in estuarine sediments that degrade DEHP, with Acidovorax and Sedimenticola as key degraders and horizontal gene transfer playing a role in DEHP degradation capacity.

SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy

This study shows that SARS-CoV-2 infection reduces KLF2 in human lung autopsies, linking KLF2 down-regulation to vascular dysfunction in ARDS.

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

Genome-Enabled Discovery of Anthraquinone Biosynthesis in Senna tora

The paper identifies a CHS-L gene responsible for anthraquinone biosynthesis in S. tora using genomics, transcriptomics, metabolomics, and biochemistry.

Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation

The paper identifies a bacterial strain capable of converting estrogens into androgens via cobalamin-mediated methylation, revealing a novel metabolic pathway.

Non-uniform Crowding Enhances Transport: Relevance to Biological Environments

The paper shows that non-uniform crowder distributions enhance tracer transport in biological environments, with implications for intracellular transport mechanisms.