J. Cole

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohns disease associated adherent-invasive Escherichia coli infection

The paper identifies novel therapeutic targets for AIEC infection by stratifying macrophages based on bacterial load and showing that targeting these pathways reduces AIEC replication.

Interactions between ploidy and resource availability shape clonal interference at initiation and recurrence of glioblastoma

This study uses a mathematical model to show that ploidy and resource availability in the tumor microenvironment influence glioblastoma initiation and recurrence.

Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

This paper develops Svg3, a cGAS-agonistic oligonucleotide, showing enhanced IFN-I responses and improved immunotherapy efficacy in preclinical models.

An intact S-layer is advantageous to Clostridioides difficile within the host.

This paper shows that an intact S-layer in Clostridioides difficile enhances disease severity by analyzing revertants of an S-layer-null strain and their gene expression differences.

Climate stress and its impact on livestock health, farming livelihoods and antibiotic use in Karnataka, India

This paper examines the relationship between climate variables and livestock diseases in Karnataka, India, identifying key climate factors and proposing a risk classification method using meteorological and epidemiological data.

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2

This paper evaluates two BNT162b vaccine candidates in non-human primates, showing they are immunogenic and protect against SARS-CoV-2 infection.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

This paper reports on a prefusion SARS-CoV-2 spike RNA vaccine that induces strong immune responses and prevents lung infection in non-human primates.

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

This study identifies transcriptional signatures of IFN signaling and neutrophil degranulation in SARS-CoV-2 infected rhesus macaques and humans, highlighting age-related differences and shared pathways with tuberculosis.

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

The essential genome of Escherichia coli K-12

This study benchmarks TraDIS against single gene deletion libraries to identify essential genes in E. coli, revealing new essential genes and correcting previous designations.

MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis

The paper identifies and characterizes MCE domain proteins in E. coli, showing they localize to the inner membrane and play distinct roles in maintaining outer membrane lipid asymmetry.