M. Graos

Mimicking physiological stiffness or oxygen levels in vitro reorganizes mesenchymal stem cells machinery toward a more naive phenotype

This paper shows that culturing MSCs on soft substrates or under low oxygen levels alters their proteome, promoting a more naive phenotype by affecting redox homeostasis, protein chaperones, and translational complexity.

A generic normalization method for proper quantification in untargeted proteomics screening

This paper introduces a normalization method using recombinant proteins as internal standards for untargeted label-free proteomics, showing comparable performance to existing methods while preserving proteome changes between groups.