Author

M. Gruebele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Animal Behavior & Cognition· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:statistical model· 2

Frequent Co-Authors

M. M. Rickard· 2 shared Z. Ghaemi· 2 shared A. S. Ravan· 1 shared D. Cai· 1 shared D. Feliciano· 1 shared E. Flores· 1 shared E. Tajkhorshid· 1 shared J. Lippincott-Schwartz· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

M. M. Rickard

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Author profile →

6 papers

Recent·Most cited

Rapid automated 3-D pose estimation of larval zebrafish using a physical model-trained neural network

A. S. Ravan, R. Feng, M. Gruebele, Y. R. Chemla

This paper introduces a method to automatically estimate 3-D poses of larval zebrafish using a neural network trained on synthetic data, achieving high speed and accuracy for ethological studies.

bioRxiv · Jan 6, 2023Animal Behavior & Cognition

Cytoplasmic folding, mis-folding, and early stages of aggregation

P. P. Samuel Russell, M. M. Rickard, M. Boob, M. Gruebele, T. V. Pogorelov

The paper examines how cytoplasmic interactions affect the early folding and aggregation of Protein B in an all-atom model of human cytoplasm.

bioRxiv · Oct 23, 2022 · PreprintBiophysics

Metabolons, quinary structure, and domain motion: enzyme choreography in the cytoplasm

P. P. Samuel, M. M. Rickard, T. V. V. Pogorelov, M. Gruebele

The paper simulates a human cytoplasm model to study metabolon formation, revealing enzyme interactions, quinary structure, and domain motion in glycolytic enzymes.

bioRxiv · Sep 13, 2022 · PreprintBiophysics

Molecular Mechanism of Capsid Disassembly in Hepatitis B Virus

Z. Ghaemi, M. Gruebele, E. Tajkhorshid

This study uses molecular dynamics simulations to reveal how mechanical stress and thermal fluctuations cause HBV capsid disassembly by targeting specific residues in hexameric regions.

bioRxiv · Feb 8, 2021Biophysics

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

D. Cai, D. Feliciano, P. Dong, E. Flores, M. Gruebele, N. Porat-Shliom, S. Sukenik, Z. Liu, J. Lippincott-Schwartz

This study shows YAP forms liquid-like condensates that reorganize genome topology to enable long-term target gene expression.

bioRxiv · Jul 29, 2019Cell Biology

An In-Silico Mammalian Whole-Cell Model Reveals the Influence of Spatial Organization on RNA Splicing Efficiency

Z. Ghaemi, J. Peterson, M. Gruebele, Z. Luthey-Schulten

The paper develops a spatially-resolved whole HeLa cell model to study how spatial organization affects RNA splicing efficiency and particle assembly.

bioRxiv · Oct 8, 2018Biophysics