S. Sukenik

Disordered proteins interact with the chemical environment to tune their protective function during drying

This study investigates how disordered proteins interact with endogenous cosolutes during drying to enhance desiccation protection across different organisms.

Rational design of disordered proteins for systematic sequence-to-function investigation

This paper introduces GOOSE, a computational framework for designing intrinsically disordered proteins, and demonstrates its ability to create IDRs with specific functional responses.

Helicity of a tardigrade disordered protein promotes desiccation tolerance

This study shows that helical structure in a tardigrade IDP is necessary for desiccation tolerance, but not sufficient on its own.

Labile assembly of a tardigrade protein induces biostasis

This study identifies a mechanism by which tardigrade CAHS D proteins form gels to protect cells during desiccation, showing that gelation reduces molecular motion and metabolic activity, with reversible effects.

Structural preferences shape the entropic force of disordered protein ensembles

The paper uses all-atom simulations to show that sequence-encoded structural preferences in disordered protein regions influence the magnitude of entropic forces generated upon tethering.

YAP condensates are highly organized hubs for YAP/TEAD transcription

This study shows YAP forms organized condensates under Hippo pathway and actin tension, which stabilize YAP and recruit coactivators to enhance transcription.

Structural biases in disordered proteins are prevalent in the cell

The paper shows that structural biases in intrinsically disordered proteins persist in human cells and can respond to intracellular changes.

Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms

This study identifies CAHS D as a tardigrade protein that protects against desiccation through multiple mechanisms involving water coordination and slowed molecular motion.

Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

The paper develops a FRET biosensor using intrinsically disordered proteins to monitor osmotic stress effects across multiple organisms.

Modeling the Opening SARS-CoV-2 Spike: an Investigation of its Dynamic Electro-Geometric Properties

This study computes electrostatic properties of the SARS-CoV-2 spike protein's opening using exascale simulations and continuum modeling to support pharmacological research.

Probing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment

This study develops a framework to characterize how intrinsically disordered proteins (IDRs) respond to their chemical environment, finding sequence-dependent sensitivity and potential regulatory roles.

Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.

This study identifies FLOE1, a prion-like protein in Arabidopsis thaliana, whose hydration-dependent phase separation regulates seed germination under water stress.

Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome

The paper identifies myomegalin's role in regulating the Hedgehog pathway by tethering PDE4D3 to the centrosome, showing its impact on medulloblastoma growth.

Controlling Structural Bias in Intrinsically Disordered Proteins Using Solution Space Scanning

This study introduces a computational method to alter solution conditions and control residual structure in intrinsically disordered proteins, offering an alternative to mutational studies.

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

This study shows YAP forms liquid-like condensates that reorganize genome topology to enable long-term target gene expression.