Author

M. Gutova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

R. C. Rockne· 3 shared X. Yang· 3 shared A. B. Brummer· 2 shared C. Brown· 2 shared C. E. Brown· 2 shared D. Wang· 2 shared M. Barish· 2 shared A. Brito· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioengineering

R. C. Rockne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Model discovery approach enables non-invasive measurement of intra-tumoral fluid transport in dynamic MRI

R. T. Woodall, C. C. Esparza, M. Gutova, M. Wang, J. Cunningham-Reynolds, A. B. Brummer, C. Stine, C. Brown, J. M. Munson, R. C. Rockne

A physics-informed computational method measures fluid dynamics in tumors, showing differences in fluid velocity between breast and brain cancer tissues.

bioRxiv · Aug 28, 2023 · PreprintBioengineering

Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy

A. B. Brummer, X. Yang, E. Ma, M. Gutova, C. E. Brown, R. C. Rockne

This paper uses a mathematical model to show that dexamethasone destabilizes CAR T-cell efficacy in glioblastoma by altering coexistence dynamics and introducing critical thresholds.

bioRxiv · Oct 1, 2021Cancer Biology

Chlorotoxin Redirects Chimeric Antigen Receptor T Cells for Specific and Effective Targeting of Glioblastoma

D. Wang, R. Starr, W.-C. Chang, B. Aguilar, D. Alizadeh, S. L. Wright, X. Yang, A. Brito, A. Sarkissian, J. R. Ostberg, Y. Shi, M. Gutova, K. Aboody, B. Badie, S. J. Forman, , C. Brown

This study develops a CAR T cell therapy using chlorotoxin to target glioblastoma with high specificity and potency, overcoming tumor heterogeneity challenges.

bioRxiv · Jan 24, 2020 · PreprintImmunology

Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data

P. Sahoo, X. Yang, D. Abler, D. Maestrini, V. Adhikarla, D. Frankhouser, H. Cho, V. Machuca, D. Wang, M. Barish, M. Gutova, S. Branciamore, C. E. Brown, R. C. Rockne

This paper uses a mathematical model to analyze CAR T-cell killing dynamics in glioma, showing dose-dependent effects on proliferation and exhaustion.

bioRxiv · Nov 9, 2019Immunology