W.-C. Chang

B cell repertoire of children with atopic dermatitis exhibit altered IgE maturationassociated with allergic food sensitization

The paper examines IgE B cell repertoires in children with atopic dermatitis, finding altered IgE maturation linked to allergic food sensitization and pet ownership effects.

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2 in vitro

This study identifies OPCs and punicalagin as potent inhibitors of SARS-CoV-2 infection, with punicalagin showing the strongest activity against omicron variants and viral entry.

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

This study develops TAG72-CAR T cells with antigen-dependent IL-12 signaling to enhance anti-tumor activity and systemic disease targeting in ovarian cancer.

The anti-platelet drug cilostazol enhances interrenal steroidogenesis and exerts a scant effect on innate immune responses in zebrafish

This study shows cilostazol enhances steroidogenesis in zebrafish interrenal tissue but has minimal impact on innate immune responses during tissue injury and repair.

Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-Stimulation

This study compares IL13-ligand CAR designs to determine how co-stimulation domains affect tumor selectivity and anti-tumor activity against glioblastoma.

Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity

This study shows that cyclophosphamide pre-conditioning improves CAR T cell efficacy against solid tumors by modifying the immunosuppressive tumor microenvironment without harming normal tissues.

Chlorotoxin Redirects Chimeric Antigen Receptor T Cells for Specific and Effective Targeting of Glioblastoma

This study develops a CAR T cell therapy using chlorotoxin to target glioblastoma with high specificity and potency, overcoming tumor heterogeneity challenges.

TET1 and TDG suppress intestinal tumorigenesis by down regulating the inflammatory and immune response pathways

This study shows that TET1 and TDG reduce intestinal tumor formation by suppressing inflammatory and immune response pathways through DNA demethylation.

Low-Density Lipoprotein Receptor-Mediated Lipidome-Transcriptome Reprogramming Impulses to Cisplatin Insensitivity

This study identifies LDLR-mediated lipidome-transcriptome reprogramming as a mechanism for cisplatin insensitivity in ovarian cancer and demonstrates a lipid-based drug delivery strategy to enhance chemotherapy efficacy.

Three-dimensional culture of chicken primordial germ cells in chemically defined media containing the functional polymer FP003

This study develops a 3D culture system for chicken primordial germ cells using chemically defined media, enabling scalable expansion and maintenance of cellular properties.