Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche
M. Haroon, J. Klein-Nulend, A. D. Bakker, J. Jin, C. Offringa, F. Le Grand, L. Giordani, K. J. Liu, R. D. Knight, R. T. Jaspers
This study shows that muscle stem cells in their native niche experience mechanical deformation from myofiber stretch-shortening and respond with increased nitric oxide production and gene expression related to proliferation.
bioRxiv · Jan 14, 2020Cell Biology