Structural insight into tanapoxvirus mediated inhibition of apoptosis
C. D. Suraweera, M. I. Anasir, S. Chugh, A. Javorsky, R. E. Impey, M. Hasan Zadeh, T. P. Soares da Costa, M. G. Hinds, M. Kvansakul
This study determines the crystal structures of TANV16L bound to Bax, Bim, and Puma BH3, revealing its mechanism of inhibiting apoptosis by adopting monomeric and dimeric forms while maintaining the canonical ligand binding groove.
The FEBS Journal · May 31, 2020Peer-reviewedMicrobiology