Author

M. Kvansakul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Assay:structural biology· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

P. O. Humbert· 3 shared B. Z. Stewart· 2 shared C. D. Suraweera· 2 shared M. G. Hinds· 2 shared S. Caria· 2 shared A. Javorsky· 1 shared D. R. Burton· 1 shared J. Y. How· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

P. O. Humbert

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural analysis of human papillomavirus E6 interactions with Scribble PDZ domains

B. Z. Stewart, S. Caria, P. O. Humbert, M. Kvansakul

This study identifies the Scribble PDZ1 and PDZ3 domains as key interactors of HPV E6 proteins and determines their structural interactions with E6 PBM motifs from high-risk HPV strains.

bioRxiv · Oct 12, 2022Biochemistry

Structural basis of the human Scribble-Vangl2 association in health and disease

J. Y. How, R. Stephens, K. Y. B. Lim, P. O. Humbert, M. Kvansakul

This study determines the crystal structures of Scribble PDZ domains bound to Vangl2 and shows how mutations disrupt interactions with multiple signaling regulators.

bioRxiv · Oct 7, 2020Cell Biology

Structural insight into tanapoxvirus mediated inhibition of apoptosis

C. D. Suraweera, M. I. Anasir, S. Chugh, A. Javorsky, R. E. Impey, M. Hasan Zadeh, T. P. Soares da Costa, M. G. Hinds, M. Kvansakul

This study determines the crystal structures of TANV16L bound to Bax, Bim, and Puma BH3, revealing its mechanism of inhibiting apoptosis by adopting monomeric and dimeric forms while maintaining the canonical ligand binding groove.

The FEBS Journal · May 31, 2020Peer-reviewedMicrobiology

Crystal structures of the sheeppoxvirus encoded inhibitor of apoptosis SPPV14 bound to Hrk and Bax BH3 peptides

C. D. Suraweera, D. R. Burton, M. G. Hinds, M. Kvansakul

This study determines the crystal structures of SPPV14 bound to BH3 peptides from Bax and Hrk, revealing an ionic interaction that mimics host Bcl-2:BH3 complexes to inhibit apoptosis.

bioRxiv · Mar 10, 2020Microbiology

Structural analysis of phosphorylation-associated interactions of MCC to Scribble PDZ domains

S. Caria, B. Z. Stewart, P. O. Humbert, M. Kvansakul

The paper investigates how phosphorylation affects Scribble PDZ domains' interactions with MCC, showing that phosphorylation at the -1 Ser position has limited impact on binding.

bioRxiv · Dec 19, 2018Biochemistry