Author

M. Iravani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. van Weverwijk· 2 shared C. Isacke· 2 shared D. Vicente· 2 shared Q. Gao· 2 shared S. Haider· 2 shared U. Jungwirth· 2 shared A. Fitzpatrick· 1 shared A. Mills· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

A. van Weverwijk

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3 papers

Recent·Most cited

Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis reveals acquisition of a lobular-like phenotype

A. Fitzpatrick, M. Iravani, A. Mills, D. Vicente, T. Alaguthurai, I. Roxanis, N. C. Turner, S. Haider, A. N. J. Tutt, C. Isacke

This study analyzes genomic changes in breast cancer leptomeningeal metastasis using CSF samples, identifying unique genetic features and potential therapeutic targets.

bioRxiv · Jan 20, 2023Cancer Biology

Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

U. Jungwirth, A. van Weverwijk, L. Jenkins, J. Alexander, D. Vicente, Q. Gao, S. Haider, M. Iravani, C. M. Isacke

The paper identifies a specific cancer-associated fibroblast subset that supports tumour growth and metastasis by expressing Endo180, and shows that targeting this subset can limit tumour progression.

bioRxiv · May 17, 2020Cancer Biology

Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

A. van Weverwijk, N. Koundouros, M. Iravani, M. Ashenden, Q. Gao, G. Poulogiannis, U. Jungwirth, C. Isacke

This study identifies AKR1B10 as a metastasis enhancer that promotes tumour growth in secondary sites by balancing glycolysis and fatty acid oxidation.

bioRxiv · Jul 11, 2018Cancer Biology