Mutational screens highlight glycosylation as a modulator of CSF3R activity
M. J. Hollander, S. A. Malaker, I. Perez, J. E. Maxson, J. R. Cochran, C. R. Bertozzi
The paper identifies glycosylation sites as critical for CSF3R activity and shows that mutations at these sites can lead to ligand-independent cell growth in chronic neutrophilic leukemia.
bioRxiv · Aug 1, 2022 · PreprintBiochemistry