V. M. Weaver

Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.

This study shows that uptake of tumor-derived microparticles by macrophages in the early metastatic lung leads to metabolic reprogramming and altered function.

Coenzyme A governs proinflammatory macrophage metabolism

This study shows that exogenous CoA enhances TLR-driven proinflammatory and antimicrobial responses in macrophages by promoting oxidative metabolism and histone acetylation.

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

The paper shows that stiff extracellular matrix and integrin mechanosignaling increase mammary stem-progenitor cells, promoting breast cancer risk and progression through RANK signaling.

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

Adhesion-mediated mechanosignaling forces mitohormesis

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

Spatiotemporal mosaic patterning of pluripotent stem cells using CRISPR interference

This study uses CRISPR interference to create spatiotemporal patterns in hiPSC colonies, revealing how gene knockdowns affect multicellular organization and symmetry breaking during development.

A Bulky Glycocalyx Fosters Metastasis Formation by Promoting G1 Cell Cycle Progression

This study shows that a bulky glycocalyx promotes metastasis by enabling G1 cell cycle progression through integrin adhesion and signaling.