ImmunologybioRxiv
The polybasic cleavage site in the SARS-CoV-2 spike modulates viral sensitivity to Type I IFN and IFITM2
H. Winstone, M. J. Lista Brotos, A. Reid…·S. Neil
This paper shows that the polybasic cleavage site in SARS-CoV-2 spike protein reduces sensitivity to IFITM2 and type I IFNs, enhancing viral replication and transmission.
DOI 10.1128/jvi.02422-20