Author

S. Neil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

C. M. Swanson· 5 shared H. Wilson· 3 shared H. Winstone· 3 shared M. Palmarini· 2 shared R. P. Galao· 2 shared S. Pickering· 2 shared A. Davidson· 1 shared A. Dyer· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersMicrobiology

C. M. Swanson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The P681H mutation in the Spike glycoprotein confers Type I interferon resistance in the SARS-CoV-2 alpha (B.1.1.7) variant

M. J. Lista, H. Winstone, H. Wilson, A. Dyer, S. Pickering, R. P. Galao, G. De Lorenzo, V. Cowton, W. Furnon, N. M. Suarez, R. Orton, M. Palmarini, A. H. Patel, L. B. Snell, G. Nebbia, , S. Neil

This study shows the P681H mutation in the SARS-CoV-2 alpha variant's Spike protein confers resistance to Type I interferon, enhancing viral replication by evading innate immune responses.

bioRxiv · Nov 9, 2021 · PreprintMicrobiology

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

H. Khan, H. Winstone, J. Jimenez-Guardeno, C. Graham, K. Doores, C. Goujon, D. Matthews, A. Davidson, S. Rihn, M. Palmarini, S. Neil, M. Malim

This study shows that NCOA7 restricts SARS-CoV-2 infection by promoting endosomal acidification, and TMPRSS2 or removal of the furin cleavage site reduces this restriction.

bioRxiv · Jul 23, 2021Microbiology

TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction

R. P. Galao, H. Wilson, K. L. Schierhorn, F. Debeljak, B. S. Bodmer, D. Goldhill, T. Hoenen, S. J. Wilson, C. M. Swanson, S. Neil

This study identifies TRIM25 and ZAP as key factors in type I interferon-mediated inhibition of Ebola virus replication by targeting the viral ribonucleoprotein complex.

bioRxiv · May 23, 2021Microbiology

The polybasic cleavage site in the SARS-CoV-2 spike modulates viral sensitivity to Type I IFN and IFITM2

H. Winstone, M. J. Lista Brotos, A. Reid, S. Pickering, K. J. Doores, C. M. Swanson, S. Neil

This paper shows that the polybasic cleavage site in SARS-CoV-2 spike protein reduces sensitivity to IFITM2 and type I IFNs, enhancing viral replication and transmission.

bioRxiv · Dec 19, 2020Immunology

The Zinc Finger Antiviral Protein restricts SARS-CoV-2

R. Nchioua, D. Kmiec, J. Mueller, C. Conzelmann, R. Gross, C. M. Swanson, S. Neil, S. Stenger, D. Sauter, J. Muench, K. M. Sparrer, F. Kirchhoff

This paper identifies ZAP as an IFN-induced antiviral effector that restricts SARS-CoV-2 by targeting CpG dinucleotides, though SARS-CoV-2 may be adapted to low CpG environments.

bioRxiv · Jun 4, 2020Microbiology

KHNYN is essential for ZAP-mediated restriction of HIV-1 containing clustered CpG dinucleotides

M. Ficarelli, H. Wilson, R. Pedro Galao, S. Neil, C. M. Swanson

The paper identifies KHNYN as a novel ZAP cofactor essential for restricting HIV-1 with clustered CpG dinucleotides.

bioRxiv · Mar 18, 2019 · PreprintImmunology