Author

K. J. Doores

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 10 Microbiology· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 16 Research Focus:host-pathogen & immune response· 15 Organism:human· 11 Assay:proteomics· 9 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Seow· 7 shared C. Graham· 6 shared M. H. Malim· 5 shared L. E. McCoy· 4 shared L. Muir· 4 shared A. Kurshan· 3 shared C. Rees-Spear· 3 shared I. Huettner· 3 shared

Activity by Year

2020-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersImmunology

J. Seow

Mutual co-authors in cluster

Author profile →

16 papers

Recent·Most cited

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

S. Griffith, L. Muir, O. Suchanek, J. Hope, C. Pade, J. M. Gibbons, Z. K. Tuong, A. Fung, E. Touizer, C. Rees-Spear, A. Nans, C. Roustan, Y. Alguel, D. Fink, C. Orkin, , L. E. McCoy

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

bioRxiv · Feb 5, 2024 · PreprintMicrobiology

The complement pattern recognition molecule CL-11 promotes invasion and injury of respiratory epithelial cells by SARS-CoV-2.

A. Polycarpou, T. Wagner-Gamble, R. Greenlaw, L. A. O'Neill, H. Khan, M. M. Malim, M. Romano, D. Smolarek, K. J. Doores, R. Wallis, L. S. Klavinskis, S. Sacks

This study shows CL-11 promotes SARS-CoV-2 invasion and injury of respiratory epithelial cells, suggesting CL-11 blockade could limit viral pathogenicity.

bioRxiv · Dec 11, 2023 · PreprintImmunology

Broad and potent neutralizing mAbs are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection

J. Seow, Z. A. Shalim, C. Graham, S. Kimuda, A. Pillai, T. Lechmere, A. Kurshan, A. Khimji, L. Snell, G. Nebbia, C. Mant, A. Waters, J. Fox, M. H. Malim, K. J. Doores

The paper shows that vaccinated individuals develop broad neutralizing mAbs after Delta/BA.1 infection, but these mAbs are less effective against newer variants.

bioRxiv · Mar 30, 2023 · PreprintImmunology

A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease

V. A. Avanzato, T. Bushmaker, K. Y. Oguntuyo, K. C. Yinda, H. M. E. Duyvesteyn, R. Stass, K. Meade-White, R. Rosenke, T. Thomas, G. Saturday, K. J. Doores, B. Lee, T. Bowden, V. Munster

This study identifies a monoclonal antibody, mAb92, that targets the Nipah virus fusion glycoprotein and provides complete protection in hamsters.

bioRxiv · Sep 26, 2022Microbiology

Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

B. J. Willett, A. Kurshan, N. Thakur, J. Newman, M. Manali, G. Tyson, N. Logan, P. R. Murcia, L. B. Snell, J. D. Edgeworth, J. Zhou, K. Sukhova, G. Amirthalingam, K. Brown, B. Charleston, , T. P. Peacock

This study compares the antigenic properties of SARS-CoV-2 Omicron variants BA.4 and BA.5 with BA.1, BA.2, and vaccine-induced antibodies, finding they are antigenically distinct and show enhanced neutralisation breadth after breakthrough infection.

bioRxiv · May 25, 2022 · PreprintMicrobiology

Omicron breakthrough infections in vaccinated or previously infected hamsters

J. Zhou, K. Sukhova, P. F. McKay, A. Kurshan, Y. Yau, T. Lechmere, J. C. Brown, M. Moshe, R. Kugathasan, L. B. Snell, J. D. Edgeworth, R. J. Shattock, K. J. Doores, T. P. Peacock, W. S. Barclay

This study shows Delta and Omicron SARS-CoV-2 variants do not provide cross-protective immunity against reinfection in hamsters.

bioRxiv · May 20, 2022Microbiology

VelcroVax: a bolt-on vaccine platform technology improves antibody titres against a viral glycoprotein in mice

N. J. Stonehouse, N. J. Kingston, K. Grehan, J. S. Snowden, M. Hassall, J. Alzahrani, G. C. Paesen, L. Sherry, C. R. Hayward, A. Roe, S. Stephen, D. C. Tomlinson, A. Zeltina, K. J. Doores, N. A. Ranson, , D. J. Rowlands

VelcroVax is a vaccine platform that enhances antibody titres against a viral glycoprotein in mice by combining a modified VLP with a SUMO-tagged antigen.

bioRxiv · Apr 22, 2022 · PreprintImmunology

Modular capsid decoration boosts adenovirus vaccine-induced humoral and cellular immunity against SARS-CoV-2

M. D. J. Dicks, L. M. Rose, L. A. H. Bowman, C. Graham, K. J. Doores, M. H. Malim, S. J. Draper, M. Howarth, S. Biswas

This paper describes a method to enhance adenovirus vaccine efficacy by decorating capsid surfaces with antigens, resulting in improved humoral immunity and retained T cell responses.

bioRxiv · Feb 20, 2022Bioengineering

ChAdOx1 nCoV-19 (AZD1222) vaccine elicits monoclonal antibodies with potent cross-neutralizing activity against SARS-CoV-2 viral variants

J. Seow, C. Graham, S. R. Hallett, T. Lechmere, T. J. A. Maguire, I. Huettner, D. Cox, R. Roberts, A. Waters, C. C. Ward, C. Mant, M. J. Pitcher, J. Spencer, J. Fox, M. H. Malim, K. J. Doores

This study isolates monoclonal antibodies from a vaccinated individual and shows they neutralize multiple SARS-CoV-2 variants effectively.

bioRxiv · Sep 27, 2021Immunology

SARS-CoV-2-specific memory B cells can persist in the elderly despite loss of neutralising antibodies

A. Jeffery-Smith, A. R. Burton, S. Lens, C. Rees-Spear, M. Patel, R. Gopal, L. Muir, F. Aiano, K. J. Doores, J. Y. Chow, S. N. Ladhani, M. Zambon, L. E. McCoy, M. K. Maini

Circulating class-switched spike and RBD-specific memory B cells can outlast detectable neutralising antibodies but are functionally constrained in the elderly.

bioRxiv · May 30, 2021 · PreprintImmunology

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

S. Gee, M. Chandiramani, J. Seow, C. Modestini, A. Das, K. J. Doores, R. M. Tribe, D. L. Gibbons

This study examines the impact of maternal SARS-CoV-2 infection on neonatal immunology, finding increased pro-inflammatory cytokines and immune cell percentages in infants exposed in utero.

bioRxiv · May 27, 2021Immunology

ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies

C. A. Fielding, P. Sabberwal, J. C. Williamson, E. J. Greenwood, E. Crozier, W. Zelek, J. Seow, C. Graham, I. Huettner, J. Edgeworth, B. P. Morgan, K. Ladell, M. Eberl, I. R. Humphreys, B. Merrick, , R. J. Stanton

This study identifies ADNKA as a mechanism by which SARS-CoV-2-infected cells evade NK cell inhibition, showing that non-spike antibodies drive sustained NK activation and cytokine production.

bioRxiv · Apr 6, 2021Immunology

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

C. Graham, J. Seow, I. Huettner, H. Khan, N. Kouphou, S. Acors, H. Winstone, S. Pickering, R. Pedro Galao, M. Jose Lista, J. M. Jimenez-Guardeno, A. G. Laing, Y. Wu, M. Joseph, L. Muir, , K. J. Doores

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

bioRxiv · Feb 3, 2021 · PreprintImmunology

The impact of Spike mutations on SARS-CoV-2 neutralization

C. Rees-Spear, L. Muir, S. A. Griffith, J. Heaney, Y. Aldon, J. Snitselaar, P. Thomas, C. Graham, J. Seow, N. Lee, A. Rosa, C. Roustan, C. F. Houlihan, R. W. Sanders, R. K. Gupta, , L. E. McCoy

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

bioRxiv · Jan 15, 2021 · PreprintImmunology

The polybasic cleavage site in the SARS-CoV-2 spike modulates viral sensitivity to Type I IFN and IFITM2

H. Winstone, M. J. Lista Brotos, A. Reid, S. Pickering, K. J. Doores, C. M. Swanson, S. Neil

This paper shows that the polybasic cleavage site in SARS-CoV-2 spike protein reduces sensitivity to IFITM2 and type I IFNs, enhancing viral replication and transmission.

bioRxiv · Dec 19, 2020Immunology

Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody

I. Rissanen, R. Stass, S. A. Krumm, J. Seow, R. J. G. Hulswit, G. C. Paesen, J. Hepojoki, O. Vapalahti, A. Lundkvist, O. Reynard, V. Volchkov, K. J. Doores, J. T. Huiskonen, T. A. Bowden

This study investigates how a monoclonal antibody neutralizes hantaviruses by targeting the glycoprotein lattice, revealing structural insights into antibody binding and its impact on viral entry.

bioRxiv · Apr 17, 2020Microbiology