M. J. Tuazon Kels

Poxvirus-encoded TNF receptor homolog dampens inflammation and protects the host from uncontrolled lung pathology and death during respiratory infection

This study shows that the ECTV CrmD protein reduces inflammation and protects mice from lethal lung disease during respiratory infection by modulating TNF, IL-6, IL-10, and IFN-γ.

TNF deficiency dysregulates inflammatory cytokine production leading to lung pathology and death during respiratory poxvirus infection

This study shows TNF deficiency during ECTV infection leads to excessive cytokine production and lung damage, which can be mitigated by STAT3 inhibition.