Author

A. Alcami

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

A. D. Lopez-Munoz· 2 shared A. Rastrojo· 2 shared R. Martin· 2 shared A. Alejo· 1 shared A. Hait· 1 shared A. Herengt· 1 shared A. Knudsen· 1 shared A. L. Thielke· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. D. Lopez-Munoz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High-throughput engineering of cytoplasmic- and nuclear-replicating large dsDNA viruses by CRISPR/Cas9

A. D. Lopez-Munoz, A. Rastrojo, R. Martin, A. Alcami

This paper optimizes CRISPR/Cas9 for high-throughput generation of marker-free recombinant large dsDNA viruses, improving efficiency and accuracy across cytoplasmic- and nuclear-replicating viruses.

bioRxiv · Jun 13, 2022Microbiology

Herpes simpex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity

A. D. Lopez-Munoz, A. Rastrojo, R. Martin, A. Alcami

This study shows HSV-2 generates more genetic diversity than HSV-1 in cell culture, leading to higher coding diversity and nonconservative mutations.

bioRxiv · Apr 9, 2021Microbiology

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

D. Olagnier, E. Farahani, J. Thyrsted, J. B. Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jorgensen, M. Thomsen, L. Reinert, M. Lappe, , C. K. Holm

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

bioRxiv · Jul 16, 2020Microbiology

Poxvirus-encoded TNF receptor homolog dampens inflammation and protects the host from uncontrolled lung pathology and death during respiratory infection

Z. Al Rumaih, M. J. Tuazon Kels, E. Ng, P. Pandey, S. M. Pontejo, A. Alejo, A. Alcami, G. Chaudhri, G. Karupiah

This study shows that the ECTV CrmD protein reduces inflammation and protects mice from lethal lung disease during respiratory infection by modulating TNF, IL-6, IL-10, and IFN-γ.

bioRxiv · Feb 24, 2020Immunology