Author

G. Chaudhri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

G. Karupiah· 4 shared P. Pandey· 3 shared E. Ng· 2 shared M. J. Tuazon Kels· 2 shared Z. Al Rumaih· 2 shared A. Aderem· 1 shared A. Alcami· 1 shared A. Alejo· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

G. Karupiah

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Simultaneous therapeutic targeting of inflammation and virus ameliorates influenza pneumonia and protects from morbidity and mortality

P. Pandey, Z. Al Rumaih, M. J. T. Kels, E. M. Ng, R. Kc, R. Malley, G. Chaudhri, G. Karupiah

This paper shows that combining antiviral and anti-inflammatory drugs reduces IAV pneumonia severity and mortality in mice by lowering viral load and inflammation.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

Poxvirus-encoded TNF receptor homolog dampens inflammation and protects the host from uncontrolled lung pathology and death during respiratory infection

Z. Al Rumaih, M. J. Tuazon Kels, E. Ng, P. Pandey, S. M. Pontejo, A. Alejo, A. Alcami, G. Chaudhri, G. Karupiah

This study shows that the ECTV CrmD protein reduces inflammation and protects mice from lethal lung disease during respiratory infection by modulating TNF, IL-6, IL-10, and IFN-γ.

bioRxiv · Feb 24, 2020Immunology

TNF deficiency dysregulates inflammatory cytokine production leading to lung pathology and death during respiratory poxvirus infection

M. J. Tuazon Kels, Z. A. Zumaih, E. Ng, P. Pandey, S. R. Ruuls, H. Korner, T. P. Newsome, G. Chaudhri, G. Karupiah

This study shows TNF deficiency during ECTV infection leads to excessive cytokine production and lung damage, which can be mitigated by STAT3 inhibition.

bioRxiv · Dec 22, 2019Immunology

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

N. W. Zammit, O. M. Siggs, P. Gray, K. Horikawa, S. R. Daley, D. B. Langley, D. Cultrone, E. K. Malle, S. N. Walters, J. E. Villanueva, J. Warren, A. Russell, M. J. Cowley, V. Gayevskiy, M. E. Dinger, , M. E. Craig

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

bioRxiv · Mar 27, 2019 · PreprintImmunology