Visualization of the HIV-1 Env Glycan Shield Across Scales
Z. T. Berndsen, S. Chakraborty, X. Wang, C. A. Cottrell, J. L. Torres, J. K. Diedrich, C. Lopez, J. R. Yates, M. J. van-Gils, J. C. Paulson, S. Gnanakaran, A. B. Ward
This study uses cryo-EM, computational modeling, and mass-spectrometry to analyze the HIV-1 Env glycan shield's structure and dynamics, revealing how heterogeneity and interactions affect epitope accessibility and trimer stability.
Proceedings of the National Academy of Sciences · Oct 22, 2020Peer-reviewedBiophysics