Author
Z. T. Berndsen
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2024 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 39 mutual co-author links8 papers
Recent·Most cited
Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus
F. Zhao, Z. T. Berndsen, N. Pedreno-Lopez, A. Burns, J. D. Allen, S. Barman, W.-H. Lee, S. Chakraborty, S. Gnanakaran, L. M. Sewall, G. Ozorowski, O. Limbo, G. Song, P. Yong, S. Callaghan, , D. Sok
This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.
bioRxiv · Dec 22, 2021Immunology
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM
A. Antanasijevic, L. M. Sewall, C. A. Cottrell, D. G. Carnathan, L. E. Jimenez, J. T. Ngo, J. B. Silverman, B. Groschel, E. Georgeson, J. Bhiman, R. Bastidas, C. LaBranche, J. D. Allen, J. Copps, H. R. Perrett, , A. B. Ward
The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.
bioRxiv · Jan 28, 2021Immunology
Visualization of the HIV-1 Env Glycan Shield Across Scales
Z. T. Berndsen, S. Chakraborty, X. Wang, C. A. Cottrell, J. L. Torres, J. K. Diedrich, C. Lopez, J. R. Yates, M. J. van-Gils, J. C. Paulson, S. Gnanakaran, A. B. Ward
This study uses cryo-EM, computational modeling, and mass-spectrometry to analyze the HIV-1 Env glycan shield's structure and dynamics, revealing how heterogeneity and interactions affect epitope accessibility and trimer stability.
Proceedings of the National Academy of Sciences · Oct 22, 2020Peer-reviewedBiophysics
Quantification of the Resilience and Vulnerability of HIV-1 Native GlycanShield at Atomistic Detail
S. Chakraborty, Z. T. Berndsen, N. W. Hengartner, B. T. Korber, A. B. Ward, S. Gnanakaran
The paper quantifies the resilience and vulnerability of HIV-1's glycan shield using atomistic modeling and graph theory, revealing new insights into its structure and potential for immunogen design.
bioRxiv · May 23, 2020Biophysics
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
Y. Watanabe, Z. T. Berndsen, J. Raghwani, G. E. Seabright, J. D. Allen, J. S. McLellan, I. A. Wilson, T. A. Bowden, A. B. Ward, M. Crispin
This study identifies vulnerabilities in coronavirus glycan shields by showing that MERS S protein has under-processed oligomannose-type glycan clusters, unlike SARS and HKU1 CoVs, and that these glycans do not form an effective shield against antibodies.
bioRxiv · Feb 20, 2020Microbiology
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
A. Antanasijevic, G. Ueda, J. Copps, P. J. Brouwer, D. Huang, J. D. Allen, C. A. Cottrell, A. Yasmeen, L. M. Sewall, I. Bontjer, T. J. Ketas, H. L. Turner, Z. T. Berndsen, P. J. Klasse, M. Crispin, , A. B. Ward
The paper evaluates de novo-designed two-component nanoparticles for presenting HIV Env trimers, showing improved antibody responses through multivalent display.
bioRxiv · Jan 31, 2020Immunology
HIV-1 Envelope and MPER antibody structures in lipid assemblies
K. Rantalainen, Z. T. Berndsen, A. Antanasijevic, T. Schiffner, X. Zhang, W.-H. Lee, J. L. Torres, L. Zhang, A. Irimia, J. Copps, K. Zhou, Y. D. Kwon, W. H. Law, C. A. Schramm, R. Verardi, , A. Ward
This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.
bioRxiv · Nov 15, 2019Immunology