Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
K. Verma, K. Saxena, R. Donaka, A. Chaphalkar, M. K. Rai, A. Shukla, Z. Zaidi, R. Dandage, D. Shanmugam, K. Chakraborty
The paper shows that metabolic states in E. coli influence proteostasis and mutational buffering through metabolite-dependent chaperone assistance, not increased chaperone levels.
bioRxiv · Mar 20, 2020Biochemistry