A. Shukla

Inositol pyrophosphate catabolism by three families of phosphatases controls plant growth and development

This study identifies three phosphatase families involved in inositol pyrophosphate catabolism in plants, showing their roles in growth, development, and nutrient signaling.

Mutational Analysis of an Antimalarial Drug Target PfATP4

The paper models PfATP4 structure using homology and validates predictions through genetic manipulation, identifying key residues for function and resistance.

Activity of Antibiotics against Burkholderia cepacia complex in Artificial Sputum Medium

This study evaluates antibiotic activity against Bcc in artificial sputum medium, revealing discrepancies between standard susceptibility tests and in vivo-like conditions.

Cauliflower mosaic virus disease spectrum uncovers novel susceptibility factor NCED9 in Arabidopsis thaliana

This study identifies NCED9 as a susceptibility factor for Cauliflower mosaic virus in Arabidopsis thaliana through genome-wide association mapping of viral accumulation differences.

Transcriptome and biochemical analysis pinpoint multi-layered molecular processes associated with iron deficiency tolerance in hexaploid wheat

This study identifies molecular and biochemical mechanisms underlying Fe deficiency tolerance in hexaploid wheat by comparing tolerant and susceptible cultivars.

Learning Free Energy Pathways through Reinforcement Learning of Adaptive Steered Molecular Dynamics

This paper develops a reinforcement learning framework to compute low free energy pathways between states using adaptive steered molecular dynamics and robotics planning.

Enhancement of mitochondrial function fosters B cell immune memory

This study shows that enhancing mitochondrial function with Mdivi-1 improves memory B cell differentiation and vaccine efficacy against influenza and SARS-CoV-2.

Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum

The paper identifies 122 putative mitochondrial proteins in Plasmodium falciparum using proximity biotinylation and mass spectrometry, with four confirmed mitochondrial proteins of unknown function.

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition for drought tolerance in Arabidopsis

This study identifies TaVIH2-3B, a wheat PPIP5K homolog, which enhances drought tolerance in Arabidopsis by modulating cell-wall composition through increased polysaccharide accumulation.

Turnip crinkle virus targets host ATG8 proteins to attenuate antiviral autophagy

This study shows that Turnip crinkle virus uses P38 to suppress antiviral autophagy by targeting ATG8 proteins, revealing a novel counterdefense mechanism in plant viruses.

Proteasome homeostasis is essential for a robust cauliflower mosaic virus infection

This study shows that the proteasome is essential for robust cauliflower mosaic virus infection and that the virus suppresses the proteasome to enhance its own replication.

Membrane insertion mechanism of the caveolae coat protein Cavin1

This study reveals how Cavin1 inserts into membranes through PI(4,5)P2-dependent adsorption and helix insertion, facilitated by flanking regions and co-assembly with Caveolin1.

Modeling alcoholic liver disease in a human Liver-Chip

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

Procentriole microtubules as drivers of centriole reduplication

The paper investigates how procentriole microtubules drive centriole reduplication, showing that their structural changes lead to centriole disengagement and reduplication during cell cycle arrests.

Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis

The paper shows that metabolic states in E. coli influence proteostasis and mutational buffering through metabolite-dependent chaperone assistance, not increased chaperone levels.

Autophagic degradation of the Cucumber mosaic virus virulence factor 2b balances antiviral RNA silencing with proviral plant fitness and virus seed transmission

This study shows autophagy degrades CMV 2b, balancing antiviral RNA silencing with plant fitness and virus transmission.

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.

Proteome specialization of anaerobic fungi during ruminal degradation of recalcitrant plant fiber

This study identifies fungal-specific carbohydrate-active enzymes involved in rumen fiber degradation, highlighting their role in complementing bacterial cellulolytic activity.

Integrative analysis of hexaploid wheat roots identifies signature components during iron starvation

This study identifies gene and metabolic signatures in hexaploid wheat roots under iron starvation, revealing key transporters and metabolites involved in Fe acquisition and response.