Caspase-mediated regulation and cellular heterogeneity of the cGAS/STING pathway in Kaposi's sarcoma-associated herpesvirus infection
T. Tabtieng, R. C. Lent, M. Kaku, A. Monago Sanchez, M. M. Gaglia
This study shows that caspase activity inhibits cGAS during KSHV infection to suppress type I IFN production, revealing a novel immune evasion mechanism and highlighting caspases as potential therapeutic targets.
bioRxiv · May 3, 2021Microbiology