Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding
H. Kamata, M. Kanamoto, Y. Tsuchiya, Y. Nakao, T. Suzuki, H. Motohashi, M. Yamamoto
The paper shows that structural instability of IKKβ promotes autophagic degradation via enhanced Keap1 binding, leading to negative regulation of NF-κB under proteotoxic stress.
bioRxiv · Sep 3, 2018Biochemistry