M. Yamamoto

Cell-autonomous thermogenesis of macrophage alters its antibacterial function

This study shows that macrophages generate heat through a cell-autonomous mechanism, which reduces their antibacterial function in cold environments.

Self-incompatibility phenotypes of SRK mutants can be predicted with high accuracy

The study identifies mutations in SRK that cause self-incompatibility defects and shows machine learning models can predict these phenotypes accurately.

In vivo CRISPR screens identify novel virulence genes among proteins of unassigned subcellular localization in Toxoplasma

The paper uses in vivo CRISPR screens to identify virulence genes among Toxoplasma proteins with unassigned subcellular localizations, finding two essential genes conserved in Apicomplexa.

5,6-dimethylxanthenone-4-acetic acid (DMXAA), a Partial STING Agonist, Competes for Human STING Activation

This paper investigates DMXAA's partial STING agonist activity and develops HHMX, a derivative that antagonizes STING-mediated immune responses in both humans and mice.

DeepLabCut-based Behavioural and Posture Analysis in a Cricket

This paper develops a system using DeepLabCut to analyze cricket behavior and posture, revealing diurnal rhythms in locomotion, feeding, and sleep-like states without human bias or physical tagging.

Genomic surveillance of antimicrobial-resistant Escherichia coli in fecal sludge and sewage in Uganda

This study uses genomic surveillance of E. coli from Ugandan fecal sludge and sewage to track antimicrobial resistance patterns and identify key resistance determinants.

Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in myoblasts by modulating the β-catenin/NF-κB signaling pathway

This study shows that iSN04, an anti-nucleolin aptamer, reduces inflammation in myoblasts by inhibiting the β-catenin/NF-κB pathway.

Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis

This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.

The gut lactic acid bacteria metabolite, 10-oxo-cis-6,trans-11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling

This study identifies 10-oxo-cis-6,trans-11-octadecadienoic acid as an anti-inflammatory metabolite that suppresses colitis in mice via NRF2 pathway activation and GPCR signaling.

Horizontal transmission of penicillin binding protein 1A caused a nationwide spread of β-lactam resistance in pneumococci

The paper traces the nationwide spread of β-lactam resistance in pneumococci through horizontal transmission of a specific PBP1A variant, highlighting its role in resistance emergence.

Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.

The paper reveals how Toxoplasma gondii inactivates Irgb6 through ROP18-mediated phosphorylation, preventing its function in host defense.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Delayed antigen-specific CD4+ T cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderly

The paper examines how delayed CD4+ T cell responses in the elderly correlate with reduced vaccine effectiveness and lower reactogenicity to SARS-CoV-2 mRNA vaccines.

Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever

This study identifies the ACOD1-itaconate pathway in macrophages as critical for restricting Coxiella burnetii replication and proposes it as a therapeutic target for Q fever.

SARS-CoV-2 Omicron spike H655Y mutation is responsible for enhancement of the endosomal entry pathway and reduction of cell surface entry pathway

This paper investigates how the H655Y mutation in the Omicron SARS-CoV-2 spike protein enhances endosomal entry and reduces cell surface entry, altering viral tropism and fusogenicity.

Chromosomal integration of blaCTX-M genes in diverse Escherichia coli isolates recovered from river water in Japan

This study characterizes the genetic contexts of blaCTX-M genes in environmental Escherichia coli isolates from river water in Japan, revealing diverse chromosomal and plasmid-associated configurations.

A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice

This study shows that β-damascone, a rose compound, activates the NRF2 pathway in dendritic cells to reduce immune responses and alleviate contact hypersensitivity in mice.

Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

This study identifies a TMPRSS2-independent metalloproteinase-dependent entry pathway for SARS-CoV-2 that requires the furin cleavage site and S2 domain of the spike protein, highlighting new therapeutic targets.

Myogenetic oligodeoxynucleotide restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium

This study shows that the oligodeoxynucleotide iSN04 restores myoblast differentiation and reverses inflammation caused by cancer-conditioned medium.

Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC, and SFH-1) in Enterobacterales isolated from surface waters in Japan

This study identifies rare carbapenemases in environmental Enterobacterales from Japan, revealing their genetic contexts and plasmid locations.

Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer

This study identifies NIK upregulation in breast cancer due to translational dysregulation, which promotes tumorigenicity by activating the non-canonical NF-κB pathway.

Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6

This study determines the crystal structures of Irgb6 in GTP-bound and nucleotide-free forms, revealing a unique PVM binding interface that explains its membrane recognition mechanism.

Crosstalk between enterocytes and innate lymphoid cells drives early IFN-g-mediated control of Cryptosporidium

This study shows enterocytes promote ILC production of IFN-gamma, which restricts Cryptosporidium growth by acting on enterocytes themselves.

Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

This study evaluates a plasmid DNA vaccine against SARS-CoV-2 using a pyro-drive jet injector, showing strong immune response and protection in rodents.

Structural basis for binding mechanism of human serum albumin complexed with cyclic peptide dalbavancin

This study determines the crystal structure of human serum albumin bound to dalbavancin, revealing the binding mechanism and structural changes involved.

Development of Arabidopsis thaliana transformants showing the self-recognition activity of Brassica rapa

This study constructs self-incompatible Arabidopsis thaliana transformants expressing Brassica rapa self-recognition activity by introducing BrSCR and a chimeric BrSRK gene, revealing haplotype-specific activity and key amino acid residues.

Comparison of 12 molecular detection assays for SARS-CoV-2

The paper compares 12 SARS-CoV-2 molecular assays using respiratory samples, finding some have 100% specificity and high sensitivity, with recommendations for use with internal controls.

Visualizing ATP Dynamics in Live Mice

The paper develops a transgenic mouse model with GO-ATeam to measure ATP dynamics in real-time across multiple organs and conditions, providing insights into ATP's role in physiology and disease.

Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers

The paper identifies NRF2-CEBPB cooperativity in promoting tumor-initiating activity in NRF2-activated NSCLCs through enhancer remodeling and the NRF2-NOTCH3 regulatory axis.

Human GBP1 differentially targets Salmonella and Toxoplasma to license recognition of microbial ligands and caspase-mediateddeath

This study identifies GBP1's differential targeting of Salmonella and Toxoplasma to regulate caspase-mediated cell death and microbial ligand recognition.