Author

H. Motohashi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

M. Yamamoto· 3 shared F. Katsuoka· 2 shared H. Anzawa· 2 shared H. Sekine· 2 shared K. Kinoshita· 2 shared N. Ota· 2 shared T. Suzuki· 2 shared Z. Liu· 2 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBiochemistry

M. Yamamoto

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

H. Sekine, H. Takeda, A. Kishino, H. Anzawa, T. Isagawa, N. Ota, N. Kato, S. Kimura, Z. Liu, K. Kato, F. Katsuoka, M. Yamamoto, F. Miura, T. Ito, M. Takahashi, , H. Motohashi

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

bioRxiv · Oct 28, 2022 · PreprintBiochemistry

Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers

K. Okazaki, H. Anzawa, Z. Liu, N. Ota, H. Kitamura, Y. Onodera, M. M. Alam, D. Matsumaru, T. Suzuki, F. Katsuoka, S. Tadaka, I. Motoike, M. Watanabe, A. Sakurada, Y. Okada, , H. Motohashi

The paper identifies NRF2-CEBPB cooperativity in promoting tumor-initiating activity in NRF2-activated NSCLCs through enhancer remodeling and the NRF2-NOTCH3 regulatory axis.

bioRxiv · Apr 24, 2020Cancer Biology

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding

H. Kamata, M. Kanamoto, Y. Tsuchiya, Y. Nakao, T. Suzuki, H. Motohashi, M. Yamamoto

The paper shows that structural instability of IKKβ promotes autophagic degradation via enhanced Keap1 binding, leading to negative regulation of NF-κB under proteotoxic stress.

bioRxiv · Sep 3, 2018Biochemistry