Hematologic and systemic metabolic alterations due to Mediterranean type II G6PD deficiency in a novel murine model
A. D'Alessandro, H. L. Howie, A. M. Hay, K. H. Dziewulska, B. Brown, M. J. Wither, M. Karafin, E. F. Stone, S. L. Spitalnik, E. A. Hod, R. O. Francis, X. Fu, T. Thomas, J. C. Zimring
This study creates a novel murine model of severe G6PD deficiency by introducing a human mutation, revealing metabolic alterations and hemolytic sequelae similar to humans.
bioRxiv · May 31, 2021 · PreprintBiochemistry