Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy
M. L. Read, K. Brookes, L. Zha, S. Manivannan, J. Kim, M. Kocbiyik, A. Fletcher, C. M. Gorvin, G. Firth, G. O. Fruhwirth, J. P. Nicola, S. Jhiang, M. D. Ringel, M. J. Campbell, K. Sunassee, , C. J. McCabe
This study identifies an acidic dipeptide in NIS that mediates AP2 binding, showing chloroquine enhances NIS membrane retention and RAI uptake in thyroid cancer.
bioRxiv · May 22, 2023 · PreprintCancer Biology