Author

G. O. Fruhwirth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Fletcher· 1 shared B. M. Davis· 1 shared C. J. McCabe· 1 shared C. M. Gorvin· 1 shared D. J. Rolfe· 1 shared D. T. Clarke· 1 shared F. L. Gervasio· 1 shared G. Firth· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. Fletcher

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2 papers

Recent·Most cited

The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

R. S. Iyer, S. R. Needham, I. Galdadas, B. M. Davis, S. K. Roberts, R. C. Man, L. C. Zanetti-Domingues, D. T. Clarke, G. O. Fruhwirth, P. J. Parker, D. J. Rolfe, F. L. Gervasio, M. L. Martin-Fernandez

This study identifies how the T766M-EGFR mutation promotes tumor growth by utilizing new oligomer assembly mechanisms in ligand-free EGFR.

bioRxiv · Jun 16, 2023 · PreprintCancer Biology

Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy

M. L. Read, K. Brookes, L. Zha, S. Manivannan, J. Kim, M. Kocbiyik, A. Fletcher, C. M. Gorvin, G. Firth, G. O. Fruhwirth, J. P. Nicola, S. Jhiang, M. D. Ringel, M. J. Campbell, K. Sunassee, , C. J. McCabe

This study identifies an acidic dipeptide in NIS that mediates AP2 binding, showing chloroquine enhances NIS membrane retention and RAI uptake in thyroid cancer.

bioRxiv · May 22, 2023 · PreprintCancer Biology