L. Zha

Dual agonism of sodium iodide symporter function in vivo

This study identifies Cu(DDC)2-alb as a dual agonist that enhances RAI uptake in thyroid cancer by stabilizing NIS and inducing thyroid transcription factors.

Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy

This study identifies an acidic dipeptide in NIS that mediates AP2 binding, showing chloroquine enhances NIS membrane retention and RAI uptake in thyroid cancer.

The impact of size on particle drainage dynamics and antibody response

This study compares the draining kinetics and immunogenicity of round and rod-shaped VLPs, finding that round VLPs are more effective in antigen presentation and induce stronger immune responses.

Development of a vaccine against the newly emerging COVID-19 virus based on the receptor binding domain displayed on virus-like particles

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

Maternal vitamin D deficiency increases the risk of obesity in male mice offspring by affecting the immune response

This study shows that maternal vitamin D deficiency increases obesity risk in male offspring by altering immune responses and adipose tissue inflammation.

The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity

This paper identifies ClbL as an amidase enzyme that forms amide bonds, contributing to colibactin's DNA cross-linking activity by incorporating electrophilic warheads into its structure.