Author

M. L. Rennie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Approach:biophysical modeling· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. Arkinson· 4 shared H. Walden· 4 shared V. K. Chaugule· 4 shared J. Streetley· 2 shared K. Lemonidis· 2 shared M. Clarke· 2 shared L. Spagnolo· 1 shared R. Toth· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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4 shared papersBiochemistry

C. Arkinson

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4 papers

Recent·Most cited

Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

K. Lemonidis, M. L. Rennie, C. Arkinson, V. K. Chaugule, M. Clarke, J. Streetley, H. Walden

This paper presents a cryo-EM structure of the FANCI-FANCD2 complex bound to DNA, showing how ubiquitination dynamics regulate its function in DNA repair.

bioRxiv · Apr 7, 2022Biochemistry

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

M. L. Rennie, C. Arkinson, V. K. Chaugule, H. Walden

The paper uses cryo-EM to reveal how ML323 inhibits USP1 by displacing part of its hydrophobic core, causing conformational changes that disrupt the active site.

bioRxiv · Apr 6, 2022Biochemistry

Structural basis of FANCD2 deubiquitination by USP1-UAF1

M. L. Rennie, C. Arkinson, V. K. Chaugule, R. Toth, H. Walden

This study determines the structural basis of FANCD2 deubiquitination by USP1-UAF1, revealing conformational changes and substrate recognition mechanisms.

bioRxiv · Dec 5, 2020Biochemistry

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

H. Walden, M. L. Rennie, K. Lemonidis, C. Arkinson, V. K. Chaugule, M. Clarke, J. Streetley, L. Spagnolo

This study identifies how ubiquitination of FANCI and FANCD2 stabilizes the ID2 complex on DNA, enhancing its affinity for double-stranded DNA and protecting ubiquitin from deubiquitination.

bioRxiv · Feb 3, 2020Biochemistry