Author

J. Streetley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

D. Bhella· 5 shared M. Clarke· 3 shared C. Arkinson· 2 shared H. Walden· 2 shared K. Lemonidis· 2 shared M. J. Conley· 2 shared M. L. Rennie· 2 shared S. Vijayakrishnan· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersMicrobiology

D. Bhella

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

K. Lemonidis, M. L. Rennie, C. Arkinson, V. K. Chaugule, M. Clarke, J. Streetley, H. Walden

This paper presents a cryo-EM structure of the FANCI-FANCD2 complex bound to DNA, showing how ubiquitination dynamics regulate its function in DNA repair.

bioRxiv · Apr 7, 2022Biochemistry

In vitro coinfection by influenza A virus and respiratory syncytial virus generates hybrid viral particles with altered structure and tropism

J. Haney, S. Vijayakrishnan, J. Streetley, K. Dee, D. Goldfarb, M. Clarke, M. Mullin, S. D. Carter, D. Bhella, P. R. Murcia

This study shows that co-infection of human lung cells with influenza A and respiratory syncytial viruses produces hybrid viral particles with altered structure and immune evasion capabilities.

bioRxiv · Aug 16, 2021 · PreprintMicrobiology

Helical Ordering of Envelope Associated Proteins and Glycoproteins in Respiratory Syncytial Virus Filamentous Virions

M. J. Conley, J. M. Short, J. Hutchings, A. M. Burns, J. Streetley, S. E. Bakker, H. Jaffery, M. Stewart, B. J. Power, G. Zanetti, R. Fearns, S. Vijayakrishnan, D. Bhella

This study uses cryoEM and cryoET to reveal helical symmetry in RSV virions, showing how M proteins and glycoproteins are organized and their implications for vaccine targets.

bioRxiv · Aug 4, 2021Microbiology

The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the vesivirus genus.

H. Sutherland, M. J. Conley, E. Emmott, J. Streetley, I. G. Goodfellow, D. Bhella

This study determines the cryo-EM structure of vesivirus 2117, revealing structural differences in the capsid that suggest variations in entry pathways among vesivirus clades.

bioRxiv · Feb 5, 2021Microbiology

Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for dynamic inter-molecular interactions involved in viral genome replication

E. A. Loundras, J. Streetley, M. R. Herod, R. F. Thompson, M. Harris, D. Bhella, N. J. Stonehouse

This study identifies higher-order structures of the foot-and-mouth disease virus RdRp and their role in RNA replication through cryo-EM and mutagenesis.

bioRxiv · Dec 17, 2020 · PreprintMicrobiology

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

H. Walden, M. L. Rennie, K. Lemonidis, C. Arkinson, V. K. Chaugule, M. Clarke, J. Streetley, L. Spagnolo

This study identifies how ubiquitination of FANCI and FANCD2 stabilizes the ID2 complex on DNA, enhancing its affinity for double-stranded DNA and protecting ubiquitin from deubiquitination.

bioRxiv · Feb 3, 2020Biochemistry

Structure of the Macrobrachium rosenbergii Nodavirus: A new genus within the Nodaviridae?

K. L. Ho, M. Gabrielsen, P. L. Beh, C. L. Kueh, T. Qiu Xian, J. Streetley, W. S. Tan, D. Bhella

This paper presents the atomic-resolution structure of Macrobrachium rosenbergii nodavirus (MrNV) using cryoEM, revealing a unique T=3 capsid with dimeric spikes and structural similarities to Tombusviridae, challenging its taxonomic classification.

bioRxiv · Aug 7, 2018Microbiology