Author

V. K. Chaugule

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:protein folding & dynamics· 5 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

C. Arkinson· 6 shared H. Walden· 6 shared M. L. Rennie· 4 shared R. Toth· 3 shared J. Streetley· 2 shared K. Lemonidis· 2 shared M. Clarke· 2 shared A. Galloway· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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6 shared papersBiochemistry

C. Arkinson

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Author profile →

7 papers

Recent·Most cited

Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

K. Lemonidis, M. L. Rennie, C. Arkinson, V. K. Chaugule, M. Clarke, J. Streetley, H. Walden

This paper presents a cryo-EM structure of the FANCI-FANCD2 complex bound to DNA, showing how ubiquitination dynamics regulate its function in DNA repair.

bioRxiv · Apr 7, 2022Biochemistry

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

M. L. Rennie, C. Arkinson, V. K. Chaugule, H. Walden

The paper uses cryo-EM to reveal how ML323 inhibits USP1 by displacing part of its hydrophobic core, causing conformational changes that disrupt the active site.

bioRxiv · Apr 6, 2022Biochemistry

Structural basis of FANCD2 deubiquitination by USP1-UAF1

M. L. Rennie, C. Arkinson, V. K. Chaugule, R. Toth, H. Walden

This study determines the structural basis of FANCD2 deubiquitination by USP1-UAF1, revealing conformational changes and substrate recognition mechanisms.

bioRxiv · Dec 5, 2020Biochemistry

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

H. Walden, M. L. Rennie, K. Lemonidis, C. Arkinson, V. K. Chaugule, M. Clarke, J. Streetley, L. Spagnolo

This study identifies how ubiquitination of FANCI and FANCD2 stabilizes the ID2 complex on DNA, enhancing its affinity for double-stranded DNA and protecting ubiquitin from deubiquitination.

bioRxiv · Feb 3, 2020Biochemistry

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

C. Arkinson, V. K. Chaugule, R. Toth, H. Walden

This study identifies the N-terminus of USP1 as critical for its specificity in deubiquitinating FANCD2, but not PCNA or FANCI.

bioRxiv · Sep 29, 2018Biochemistry

Allosteric network in Ube2T drives specificity for RING E3 catalysed ubiquitin signals.

V. K. Chaugule, C. Arkinson, R. Toth, H. Walden

The paper identifies an allosteric network in Ube2T that enhances FANCD2 ubiquitination while maintaining specificity, and reveals similar networks in other E2s.

bioRxiv · Sep 27, 2018Biochemistry

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

F. Inesta-Vaquera, A. Galloway, L. Chandler, A. Rojas-Fernandez, V. K. Chaugule, S. Weidlich, M. Peggie, V. H. Cowling

This study identifies DHX15 as a regulator of CMTR1-dependent gene expression and cell proliferation through their interaction and functional interplay in RNA processing.

bioRxiv · Mar 3, 2017Cell Biology