Splice-specific lyn knockout mice reveal a dominant function of LynB in preventing autoimmunity
B. F. Brian, M. L. Sauer, B. L. Ruis, J. L. Auger, S. E. Senevirathne, W. L. Swanson, M. G. Nunez, B. S. Moriarity, C. A. Lowell, B. A. Binstadt, T. S. Freedman
This study shows that LynB, a splice variant of Lyn, prevents autoimmunity, while its absence leads to TLR4 hyper-responsiveness and lupus-like disease.
bioRxiv · May 3, 2021 · PreprintImmunology