Author

M. Lekka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:imaging· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. Pabijan· 5 shared K. Gnanachandran· 3 shared A. Podesta· 2 shared J. Lopez Alonso· 2 shared J. Wesolowska· 2 shared M. Berardi· 2 shared A. Basta-Kaim· 1 shared A. Kubiak· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersBiophysics

J. Pabijan

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Migration, proliferation, and elasticity of bladder cancer cells on lectin-coated surfaces

M. Luty, R. Szydlak, J. Pabijan, I. H. Oevreeide, V. E. Prot, B. T. Stokke, M. Lekka

This study examines migration, proliferation, and mechanical properties of bladder cancer cells at different stages and links these traits to actin filament organization and lectin-coated surface interactions.

bioRxiv · May 12, 2024Biophysics

Changes in Secondary Structure and Properties of Bovine Serum Albumin as a Result of Interactions with Gold Surface

P. Komorek, K. Rakowski, M. Szota, M. Lekka, B. Jachimska

This study investigates how bovine serum albumin changes its structure when interacting with a gold surface, showing increased disordered structures and β-turns, and fewer α-helices, depending on concentration and pH.

bioRxiv · Nov 18, 2023 · PreprintBiochemistry

Multiscale Rheology of Aging Cancer Spheroids

K. Gnanachandran, M. Berardi, A. Skar, G. Pyka-Fosciak, J. Pabijan, J. Lopez Alonso, I. B. Akca, M. Lekka

This study presents a label-free method to analyze mechanical properties of bladder cancer spheroids at different stages of progression, revealing viscoelastic behavior and heterogeneity.

bioRxiv · Jul 31, 2023 · PreprintBiophysics

Reliable, standardized measurements for cell mechanical properties

S. Perez-Dominguez, S. G. Kulkarni, J. Pabijan, K. Gnanachandran, H. Holuigue, M. Eroles, E. Lorenc, M. Berardi, N. Antonovaite, M. L. Marini, J. Lopez Alonso, L. Redonto-Morata, V. Dupres, S. Janel, S. Acharya, , M. Lekka

The paper develops a standardized protocol for measuring mechanical properties of cancer cells using AFM, achieving consistent results across multiple laboratories.

bioRxiv · Jun 14, 2023Biophysics

Nanomechanical and microrheological properties of bladder cancer cells at cellular and spheroid levels

K. Gnanachandran, S. Kedracka-Krok, J. Pabijan, M. Lekka

This study uses AFM to measure mechanical and rheological properties of bladder cancer cells and spheroids, showing that actin filaments influence these properties and can differentiate between cancer types.

bioRxiv · Mar 21, 2022Biophysics

Changes in nanomechanical properties of single neuroblastoma cells as a model for oxygen and glucose deprivation (OGD)

T. Zielinski, J. Pabijan, B. Zapotoczny, J. Zemla, J. Wesolowska, J. Pera, M. Lekka

This study uses AFM to measure biomechanical changes in neuroblastoma cells under OGD and RO, finding cell softening linked to actin remodeling and reduced metabolic activity.

bioRxiv · Feb 19, 2022Biophysics

Stiffening of prostate cancer cells driven by actin filaments - microtubules crosstalk confers resistance to microtubule-targeting drugs

A. Kubiak, M. Chighizola, C. Schulte, N. Bryniarska, J. Wesolowska, M. Pudelek, D. Ryszawy, A. Basta-Kaim, P. Laidler, A. Podesta, M. Lekka

This study shows that prostate cancer cells stiffen in response to microtubule-targeting drugs due to actin-microtubule crosstalk, contributing to drug resistance.

bioRxiv · Jun 14, 2020Biophysics