Author

M. Chighizola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

C. Schulte· 6 shared A. Podesta· 5 shared C. Lenardi· 3 shared C. Piazzoni· 3 shared L. Varinelli· 3 shared M. Deraco· 3 shared M. Gariboldi· 3 shared M. Guaglio· 3 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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6 shared papersBiophysics

C. Schulte

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Native extracellular matrix probes to target patient- and tissue- specific cell-microenvironment interactions by force spectroscopy

H. Holuigue, L. Nacci, P. Di Chiaro, M. Chighizola, I. Locatelli, C. Schulte, M. Alfano, G. R. Diaferia, A. Podesta

The paper develops native ECM AFM probes to study cell-microenvironment interactions, showing they preserve ECM complexity and reveal region-specific adhesion patterns in bladder cancer cells.

bioRxiv · Dec 2, 2022 · PreprintBiophysics

The nanomechanical fingerprint of colorectal-derived peritoneal metastasis

E. Lorenc, L. Varinelli, M. Chighizola, S. Brich, F. Pisati, M. Guaglio, D. Baratti, M. Deraco, M. Gariboldi, A. Podesta

This study investigates the mechanical properties of extracellular matrix in colorectal cancer peritoneal metastases using AFM, finding ECM stiffening and spatial heterogeneity linked to cancer progression and clinical factors.

bioRxiv · Aug 17, 2022 · PreprintBiophysics

Force sensing on cells and tissues by atomic force microscopy

H. Holuigue, E. Lorenc, M. Chighizola, C. Schulte, L. Varinelli, M. Deraco, M. Guaglio, M. Gariboldi, A. Podesta'

This paper applies atomic force microscopy to quantify biomechanical properties of biological systems, showing correlations between mechanical changes and physiological or pathological conditions.

bioRxiv · Feb 3, 2022Biophysics

Decellularized Normal and Tumor Extracellular Matrix as Scaffold for Cancer Organoid Cultures of Colorectal Peritoneal Metastases

L. Varinelli, M. Guaglio, S. Brich, S. Zanutto, A. Belfiore, F. Zanardi, F. Iannelli, A. Oldani, E. Costa, M. Chighizola, S. P. Minardi, S. Fortuzzi, M. Filugelli, G. Garzone, F. Pisati, , M. Gariboldi

The paper develops 3D organoid cultures using decellularized ECM from colorectal peritoneal metastases to model the metastatic niche and assess chemotherapy response.

bioRxiv · Jul 15, 2021 · PreprintCancer Biology

The glycocalyx affects the mechanotransductive perception of the topographical microenvironment

M. Chighizola, T. Dini, S. Marcotti, M. D'Urso, C. Piazzoni, F. Borghi, A. Previdi, L. Ceriani, C. Folliero, B. Stramer, C. Lenardi, P. Milani, A. Podestà, C. Schulte

This study shows that glycocalyx configuration influences mechanotransductive responses of PC12 cells to nanotopographical cues through changes in actin dynamics and force loading.

bioRxiv · Mar 2, 2021Biophysics

Stiffening of prostate cancer cells driven by actin filaments - microtubules crosstalk confers resistance to microtubule-targeting drugs

A. Kubiak, M. Chighizola, C. Schulte, N. Bryniarska, J. Wesolowska, M. Pudelek, D. Ryszawy, A. Basta-Kaim, P. Laidler, A. Podesta, M. Lekka

This study shows that prostate cancer cells stiffen in response to microtubule-targeting drugs due to actin-microtubule crosstalk, contributing to drug resistance.

bioRxiv · Jun 14, 2020Biophysics

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

M. Chighizola, A. Previdi, T. Dini, C. Piazzoni, C. Lenardi, P. Milani, C. Schulte, A. Podesta'

This study uses adhesion force spectroscopy with nanostructured colloidal probes to show that nanotopography influences early mechanotransductive interactions by modulating force loading and integrin clustering in cell adhesion.

bioRxiv · Jan 2, 2020Biophysics

Neuronal Cells Confinement by Micropatterned Cluster-Assembled Dots with Mechanotransductive Nanotopography

C. Schulte, J. Lamanna, A. S. Moro, C. Piazzoni, F. Borghi, M. Chighizola, S. Ortoleva, G. Racchetti, C. Lenardi, A. Podesta, A. Malgaroli, P. Milani

This paper develops micropatterned substrates with nanotopographical features to confine and guide neuronal cell growth and differentiation through mechanotransductive signaling.

bioRxiv · Jun 14, 2018Bioengineering