Author

M. Locke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Meyerhan· 1 shared A. Reid· 1 shared A. Slee· 1 shared B. Hiller· 1 shared C. Lopez· 1 shared C. Molina-Paris· 1 shared D. Barsyte-Lovejoy· 1 shared D. Grebennikov· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

A. Meyerhan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Exploring the therapeutic potential of defective interfering particles in reducing the replication of SARS-CoV-2

M. Locke, D. Grebennikov, I. Sazonov, M. Lopez-Garcia, M. Loguinova, A. Meyerhan, G. Bocharov, C. Molina-Paris

This paper develops mathematical models to study how defective interfering particles (DIPs) reduce SARS-CoV-2 replication, showing dose-dependent inhibition in both deterministic and stochastic frameworks.

Mathematics · Jun 19, 2024Peer-reviewedMicrobiology

Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis

B. Hiller, Y. Yin, Y.-C. Perng, I. de Araujo Castro, L. Fox, M. Locke, K. Monte, C. Lopez, D. Ornitz, D. Lenschow

This study shows that FGF9 overexpression in airway epithelial cells increases type I interferon response and leads to more severe influenza A virus infection and mortality.

bioRxiv · Dec 22, 2021Immunology

Regulation of skeletal muscle metabolism and contraction performance via teneurin-latrophilin action.

A. Reid, D. Hogg, T. Dodsworth, Y. Chen, R. Reid, M. Xu, M. Husic, P. Biga, A. Slee, L. Buck, D. Barsyte-Lovejoy, M. Locke, D. Lovejoy

The paper identifies a novel teneurin/TCAP-LPHN system that regulates skeletal muscle contractility and fatigue through insulin-independent glucose importation and cytosolic Ca2+ signaling.

bioRxiv · Oct 25, 2021 · PreprintPhysiology