M. M. Abdelmageed

Acute kidney injury-induced circulating TNFR1/2 elevations correlate with persistent kidney injury and progression to fibrosis

This study shows that acute kidney injury (AKI) increases circulating TNFR1/2 levels, which correlate with kidney injury severity and progression to fibrosis, particularly through extracellular vesicle-bound forms.

EGFR-driven profibrotic signals in AKI-to-CKD transition are blocked by TNF inhibition: Opportunities for etanercept treatment

This study shows that TNF inhibition with etanercept prevents AKI-to-CKD transition and fibrosis as effectively as EGFR inhibition in mice, suggesting TNF as a downstream effector of EGFR-driven profibrotic signals.